ArtNr |
HY-P72611-100mg |
Hersteller |
MedChem Express
|
Menge |
100 mg |
Quantity options |
100 mg
100 ug
10 ug
1 ea
1 mg
2 ug
500 ug
50 ug
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Purity |
98.0 |
Sequence |
ALTSTEDPEP PSVPVPTNVL IKSYNLNPVV CWEYQNMSQT PIFTVQVKVY SGSWTDSCTN ISDHCCNIYE QIMYPDVSAW ARVKAKVGQK ESDYARSKEF LMCLKGKVGP PGLEIRRKKE EQLSVLVFHP EVVVNGESQG TMFGDGSTCY TFDYTVYVEH NRSGEILHTK HTVEKEECNE TLCELNISVS TLDSRYCISV DGISSFWQVR TEKSKDVCIP PFHDDRKD |
Citations |
[1]Castro F, et al. Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion. Front Immunol. 2018 May 4;9:847. [2]van de Vosse E, et al. IFN-γR1 defects: Mutation update and description of the IFNGR1 variation database. Hum Mutat. 2017 Oct;38(10):1286-1296. [3]Ding H, et al. Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway. Biomed Pharmacother. 2022 Nov;155:113683. [4]Goto Y, et al. Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation. Biochim Biophys Acta Mol Cell Res. 2018 Jun;1865(6):874-888. |
Smiles |
ALTSTEDPEP PSVPVPTNVL IKSYNLNPVV CWEYQNMSQT PIFTVQVKVY SGSWTDSCTN ISDHCCNIYE QIMYPDVSAW ARVKAKVGQK ESDYARSKEF LMCLKGKVGP PGLEIRRKKE EQLSVLVFHP EVVVNGESQG TMFGDGSTCY TFDYTVYVEH NRSGEILHTK HTVEKEECNE TLCELNISVS TLDSRYCISV DGISSFWQVR TEKSKDVCIP PFHDDRKD |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
IFN-gamma R1/CD119 Protein, Mouse (HEK293, His),Mouse,HEK293 |
Versandbedingung |
Gekühlt |
Lieferbar |
|
Manufacturer - Type |
Recombinant Proteins |
Shipping Temperature |
Blue Ice |
Storage Conditions |
Stored at -20°C for 2 years |
Molecular Weight |
33-57 kDa |
Product Description |
IFN-gamma R1 (CD119), one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R1 forms the functional receptor with IFN-gamma R2. Upon binding with IFN-gamma, IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1]. Then, JAK1 and JAK2 are phosphorylated and activated, and STAT1 is recruited to the receptor complex. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54)[2]. IFN-gamma R1/CD119 Protein, Mouse (HEK293, His) is a recombinant mouse IFN-gamma R1 with C-terminal 6*His tag, which is produced in HEK293 cells. |
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