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Human IGF1R/CD221 Protein (IGF-HM41R)

Human IGF1R/CD221 Protein (IGF-HM41R)

ArtNr	IGF-HM41R-500UG
Hersteller	KactusBio
Menge	500 ug
Quantity options	100 ug 500 ug
Kategorie	Oncology Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Endocrine Regulation of Lipid Metabolism Blastom
Typ	Proteins Recombinant
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	HIS, Avi
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Formula	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Sequence	Glu31-Asn932
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD221,IGF1R,IGF-1R,IGF-I R,IGF-I receptor,IGFIR,IGFR,JTK13,MGC142170,MGC142172,MGC18216
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Recombinant Protein
Manufacturer - Targets	IGF1R/CD221
Manufacturer - Conjugate / Tag	C-His-Avi
Shipping Temperature	Shipped at ambient temperature.
Storage Conditions	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Molecular Weight	The protein has a predicted MW of 105.8 kDa (alpha subunit) and 23 kDa (beta subunit). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Bis-Tris PAGE result.
Description	Recombinant Human IGF1R/CD221 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus; It contains Glu31-Asn932.
Background	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Endotoxin	Less than 1 EU per μg by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Biotinylated	no

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

IGF-HM41R-500UG-datasheet.pdf

IGF-HM41R-500UG-safety-datasheet.pdf