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Human IL-6 Protein, premium grade Europäischer Partner

ArtNr IL6-H4218-1mg
Hersteller ACROBiosystems
Menge 100 ug x 10
Quantity options 100 ug x 10 20 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Konjugat/Tag Unconjugated
Purity 95%
Citations (1) Ferguson-Smith AC,et.al. 1988, Genomics 2 (3): 203-8. (2) Schwantner A,et. al. 2004, J. Biol. Chem. 279 (1): 571-6. (3) Schuster B,et. al. 2003, J. Biol. Chem. 278 (11): 9528-35. (4) Taga T,et al.1989, Cell 58 (3): 573-81.
NCBI NP_000591
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / ActiveMax® Cytokines
Manufacturer - Conjugate / Tag
Native, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
20.8 kDa
Manufacturer - Format
Powder
Description
Human IL-6, premium grade (IL6-H4218) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Met 212 (Accession # NP_000591.1).
Background
Interleukin 6 (IL-6) is also known as HGF, BSF2, HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts, endothelial cells, et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer's Disease, systemic, lupus erythematosus, prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
Molecule
IL-6
Exp Region
Val 30 - Met 212
Characteristics
This protein carries no "tag". The protein has a calculated MW of 20.8 kDa. The protein migrates as 23-29 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.01 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug x 10
Lieferbar: In stock
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