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Human IL-7 Protein, premium grade Europäischer Partner

ArtNr IL7-H4219-1mg
Hersteller ACROBiosystems
Menge 500 ug x 2
Quantity options 500 ug x 2 20 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Konjugat/Tag Unconjugated
Purity 95%
Citations (1) Heufler C, et al. 1993, J. Exp. Med. 178 (3): 1109-14. (2) Kröncke R, et al. 1996, Eur. J. Immunol. 26 (10): 2541-4. (3) Sawa Y, et al. 2009, Immunity 30 (3): 447-57. (4) Muegge K, et al. 1993, Science 261 (5117): 93-5. (5) Noguchi M, et al. 1994, Science 262 (5141): 1877-80. (6) Snyder KM,et al. 2006, Leuk. Lymphoma 47 (7): 1222-8.
NCBI AAH47698
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias IL7,Interleukin-7
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / ActiveMax® Cytokines
Manufacturer - Conjugate / Tag
Native, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
17.4 kDa
Manufacturer - Format
Powder
Description
Human IL-7,  premium grade (IL7-H4219) is expressed from human 293 cells (HEK293). It contains AA Asp 26 - His 177 (Accession # P13232-1).
Background
Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.
Molecule
IL-7
Exp Region
Asp 26 - His 177
Characteristics
This protein carries no "tag". The protein has a calculated MW of 17.4 kDa. The protein migrates as 23 kDa and 28 kDa (±3 kDa) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.01 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug x 2
Lieferbar: In stock
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