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Human Integrin alpha 4 beta 1 (ITGA4&ITGB1) Heterodimer Protein, His Tag&Tag Free

Human Integrin alpha 4 beta 1 (ITGA4&ITGB1) Heterodimer Protein, His Tag&Tag Free

ArtNr	IT1-H52W1-1mg
Hersteller	ACROBiosystems
Menge	250 ug x 4
Quantity options	100 ug 250 ug x 4
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	90%
Citations	(1) May AE., et al.2000, Blood., 96(2), 506-13. (2) Luo BH., et al.2007, Annu Rev Immunol., 25, 619-47. (3) akada, Y., et al. 2007 Genome Biol., 8(5), 215.
NCBI	NP 000876.3 (ITGA4) , NP_002202.2 (ITGB1)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Integrin alpha 4 beta 1,ITGA4&ITGB1
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	C-10xHis \| Native, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	111.4 kDa (ITGA4) & 83.7 kDa (ITGB1)
Manufacturer - Format	Powder
Description	Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W1) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) & Gln 21 - Asp 728 (ITGB1) (Accession # P13612-1 (ITGA4) & P05556-1 (ITGB1)).
Background	Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. Integrin alpha 4 beta 1(Alpha-4/beta-1) is receptors for fibronectin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1.
Molecule	Integrin alpha 4 beta 1
Exp Region	Tyr 34 - Thr 977 (ITGA4) & Gln 21 - Asp 728 (ITGB1)
Characteristics	Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB1, has a calculated MW of 111.5 kDa (ITGA4) and 83.7 kDa (ITGB1). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The ITGA4 subunit is composed of a heavy chain (Tyr 34 - Arg 591, calculated MW 61.1 kDa) and a light chain (Ser 592 - Thr 977, calculated MW 50.4 kDa). Consequently ITGA4 migrates as 60-75 kDa, and ITGB1 as 110-140 kDa when calibrated against Star Ribbon Pre-stained Protein Marker respectively under non-reducing (NR) condition due to cleavage and glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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IT1-H52W1-1mg-datasheet.pdf

IT1-H52W1-1mg-safety-datasheet.pdf