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Human Kremen-1 protein, Fc Tag

Human Kremen-1 protein, Fc Tag

ArtNr	KR1-H5253-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 250 ug x 4
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, Fc
Purity	95%
Citations	(1) Mishra SK. et al., PLoS One. 2012;7(12): e52190. (2) Bingyu M. et al., Nature,. 2002 Jun 6;417(6889):664-7. (3) Yingzi C. et al., PNAS, 2020 117 (31) 18711-18718
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	KREMEN, KRM1,Dickkopf receptor/Kringle domain-containing transmembrane protein 1/Kringle-containing protein marking the eye and the nose
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Other Recombinant Proteins
Manufacturer - Conjugate / Tag	C-Fc, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	67.4 kDa
Manufacturer - Format	Powder
Description	Human Kremen-1, Fc Tag (KR1-H5253) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Thr 392 (Accession # Q96MU8-1).
Background	Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates. Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD).
Molecule	KREMEN1
Exp Region	Arg 21 - Thr 392
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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KR1-H5253-100ug-datasheet.pdf

KR1-H5253-100ug-safety-datasheet.pdf