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Human LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)

Human LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)

ArtNr	LIT-H5242-1mg
Hersteller	ACROBiosystems
Menge	1 mg
Quantity options	100 ug 1 mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	90%
Citations	(1) Mauri DN., et al. 1998, Immunity., 8(1), 21-30. (2) Granger SW., et al. 2003, Cytokine Growth Factor Rev., 14(3-4), 289-96. (3) Pasero C., et al. 2009, Curr Mol Med., 9(7), 911-27.
NCBI	NP 003798.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Immune Checkpoint Proteins
Manufacturer - Conjugate / Tag	N-10xHis, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	58.3 kDa
Manufacturer - Format	Powder
Description	Human LIGHT Protein, His Tag (LIT-H5242) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1) trimer Design.
Background	Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
Molecule	LIGHT
Exp Region	Asp 74 - Val 240
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 58.3 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH 7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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LIT-H5242-1mg-datasheet.pdf

LIT-H5242-1mg-safety-datasheet.pdf