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Human Mucin-1 / MUC-1 Protein, Llama IgG2b Fc Tag, low endotoxin

Human Mucin-1 / MUC-1 Protein, Llama IgG2b Fc Tag, low endotoxin

ArtNr	MU1-H5255-1mg
Hersteller	ACROBiosystems
Menge	500 ug x 2
Quantity options	100 ug 500 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated
Purity	90%
Citations	(1) Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93. (2) Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60. (3) Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311. (4) Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476. (5) Linden SK., et al., 2009, PLoS Pathog. 5 (10): e1000617.
NCBI	NP_001018016.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-LlamaFc(LlamaIgG2b), Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	42.4 kDa
Manufacturer - Format	Powder
Description	Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Background	Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Molecule	Mucin-1
Exp Region	Ser 33 - Gly 167
Characteristics	This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 42.4 kDa. The protein migrates as 50-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	0.01 EU per μg
Buffer	Tris with Glycine, Arginine and NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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MU1-H5255-1mg-datasheet.pdf

MU1-H5255-1mg-safety-datasheet.pdf