Recombinant human Smad2 protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

SMAD2 (Mothers against decapentaplegic homolog 2) belongs to the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated Smad2 is then able to form a complex with Smad4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression. Recombinant SMAD2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol

Signal Transduction

< 1 EU per 1ug of protein (determined by LAL method)

Smad2, Sma- and Mad-related protein 2 isoform 1, Sma- and Mad-related protein 2 isoform 1, hMAD-2, hSMAD2, JV18, JV18-1, MADH2, MADR2, Sma- and Mad-related protein 2 isoform 1 JV181, MAD, MAD Related Protein 2, SMAD2., ATGP0307-10ug, ATGP0307-20ug, ATGP0307-50ug, ATGP0307-100ug, ATGP0307-250ug, ATGP0307-500ug, ATGP0307-1mg, ATGP0307-10, ATGP0307-20, ATGP0307-50, ATGP0307-100, ATGP0307-250, ATGP0307-500, ATGP0307-1