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Recombinant human TC21/RRAS2 protein

ArtNr NKM-ATGP0396-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH> MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH C
Citations Erdogan M., et al. (2007) J Biol Chem. 282(38):27713-20.
Movilla N., et al. (1999) Oncogene. 18(43):5860-9.
NCBI NP_036382
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Ras-related protein R-Ras2,Related RAS viral (r-ras) oncogene homolog 2,Ras-like protein TC21,Teratocarcinoma oncogene,TC21
Similar products TC21, R-Ras2, ATGP0396-10ug, ATGP0396-20ug, ATGP0396-50ug, ATGP0396-100ug, ATGP0396-250ug, ATGP0396-500ug, ATGP0396-1mg, ATGP0396-10, ATGP0396-20, ATGP0396-50, ATGP0396-100, ATGP0396-250, ATGP0396-500, ATGP0396-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
25.2 kDa (221aa) confirmed by MALDI-TOF
Description
RAS viral (r-ras) oncogene homolog 2 isoform a, also known as RRAS2, belongs to the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. It is implicated in the pathogenesis of human cancers. Thus, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, and these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. Recombinant human RRAS2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 2mM EDTA
Antigen Species
Human
Gene Category
Cancer
Domain
1-201aa
Species of Protein
Human
Manufacturer - Search Terms
TC21, R-Ras2, ATGP0396-10ug, ATGP0396-20ug, ATGP0396-50ug, ATGP0396-100ug, ATGP0396-250ug, ATGP0396-500ug, ATGP0396-1mg, ATGP0396-10, ATGP0396-20, ATGP0396-50, ATGP0396-100, ATGP0396-250, ATGP0396-500, ATGP0396-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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