Recombinant human CLIC1 protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

CLIC1 (Chloride intracellular channel 1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. This protein is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as an anion-selective channel. It forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. Recombinant human CLIC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl

Signal Transduction

Human

Chloride intracellular channel protein 1, G6, NCC27, Chloride intracellular channel protein 1 hRNCC, Nuclear chloride ion channel 27, p64CLCP, Chloride channel ABP, Chloride intracellular channel 1, CLIC 1, NCC 27, Nuclear chloride ion channel protein, Regulatory nuclear chloride ion channel protein, RNCC protein.