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Recombinant human Thioredoxin Reductase 1/TXNRD1 protein

ArtNr NKM-ATGP0570-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH M>YDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM
Citations Ma X. et al. (2002) J Biol Chem. 277(25):22460-8.
Javvadi P. (2010) Cancer Res. 70(5):1941-50.
NCBI NP_001087240.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias GRIM 12,KDRF,KM 102 derived reductase like factor,MGC9145,Oxidoreductase,Thioredoxin reductase,Thioredoxin reductase 1,Thioredoxin reductase 1 cytoplasmic,Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein,Thioredoxin reductase GRIM 12,TR,TR 1,TRXR 1,TXNR,TXNRD 1
Similar products TXNRD1, TR1, TR, Thioredoxin reductase, GRIM-12, MGC9145, TRXR1, TXNR, TR 1, Thioredoxin reductase 1, GRIM12, KDRF, Oxidoreductase, TRXR-1, TR-1, GRIM 12, KM 102 derived reductase like factor, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, Thioredoxin reductase GRIM12, TRXR 1, TXNRD 1, TXNRD-1, ATGP0570-10ug, ATGP0570-20ug, ATGP0570-50ug, ATGP0570-100ug, ATGP0570-250ug, ATGP0570-500ug, ATGP0570-1mg, ATGP0570-010, ATGP0570-020, ATGP0570-050, ATGP0570-100, ATGP0570-250, ATGP0570-500, ATGP0570-01M
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Enzyme Activity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
55.7 kDa (508aa) confirmed by MALDI-TOF
Description
TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases. Recombinant human TXNRD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Antigen Species
Human
Gene Category
Redox Proteins
Domain
161-647aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Specific activity is > 15unit/mg, and was measured in a coupled assay with 5, 5 -Dithiobis(2-nitrobenzoic acid) (DTNB) and NADPH. The amount of TNB generated by NADPH was measured in absorbance at 412 nm.
Species of Protein
Human
Manufacturer - Search Terms
GRIM 12, GRIM12, GRIM-12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, Thioredoxin reductase GRIM12, TR, TR 1, TR1, TR-1, TRXR 1, TRXR1, TRXR-1, TXNR, TXNRD 1, TXNRD1, TXNRD-1, ATGP0570-10ug, ATGP0570-20ug, ATGP0570-50ug, ATGP0570-100ug, ATGP0570-250ug, ATGP0570-500ug, ATGP0570-1mg, ATGP0570-010, ATGP0570-020, ATGP0570-050, ATGP0570-100, ATGP0570-250, ATGP0570-500, ATGP0570-01M
Manufacturer - Alternative Names
GRIM 12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, TR, TR 1, TRXR 1, TXNR, TXNRD 1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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