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Recombinant human ITPA protein

ArtNr NKM-ATGP0639-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MMAASLVGKK IVFVTGNAKK LEEVVQILGD KFPCTLVAQK IDLPEYQGEP DEISIQKCQE AVRQVQGPVL VEDTCLCFNA LGGLPGPYIK WFLEKLKPEG LHQLLAGFED KSAYALCTFA LSTGDPSQPV RLFRGRTSGR IVAPRGCQDF GWDPCFQPDG YEQTYAEMPK AEKNAVSHRF RALLELQEYF GSLAA
Citations Clawson GA.. et al. (1991) Cell Growth Differ. 2(11):575-82.
Lin S.,et al. (2001) J Biol Chem.. 276(22):18695-701.
NCBI NP_258412
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Inosine triphosphate pyrophosphatase,C20orf37,dJ794I6.3,HLC14-06-P,ITPase,My049,OK/SW-cl.9,Inosine triphosphate pyrophosphatase
Similar products ITPA, C20orf37, Inosine triphosphate pyrophosphatase, HLC14-06-P, ITPase, dJ794I6.3, My049, OK/SW-cl.9, ATGP0639-10ug, ATGP0639-20ug, ATGP0639-50ug, ATGP0639-100ug, ATGP0639-250ug, ATGP0639-500ug, ATGP0639-1mg, ATGP0639-10, ATGP0639-20, ATGP0639-50, ATGP0639-100, ATGP0639-250, ATGP0639-500, ATGP0639-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
23.7 kDa (215aa) confirmed by MALDI-TOF
Description
ITPA, also known as Inosine triphosphate pyrophosphatase, is an enzyme that catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPA can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPA result in ITPA deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts. Recombinant human ITPA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Antigen Species
Human
Gene Category
Enzymes & Proteases
Domain
1-194aa
Species of Protein
Human
Manufacturer - Search Terms
ITPA, Inosine triphosphate pyrophosphatase, C20orf37, dJ794I6.3, HLC14-06-P, ITPase, My049, OK/SW-cl.9, Inosine triphosphate pyrophosphatase, ATGP0639-10ug, ATGP0639-20ug, ATGP0639-50ug, ATGP0639-100ug, ATGP0639-250ug, ATGP0639-500ug, ATGP0639-1mg, ATGP0639-10, ATGP0639-20, ATGP0639-50, ATGP0639-100, ATGP0639-250, ATGP0639-500, ATGP0639-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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