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Recombinant human TIGAR/C12orf5 protein

ArtNr NKM-ATGP0835-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH MGSH>MARFAL TVVRHGETRF NKEKIIQGQG VDEPLSETGF KQAAAAGIFL NNVKFTHAFS SDLMRTKQTM HGILERSKFC KDMTVKYDSR LRERKYGVVE GKALSELRAM AKAAREECPV FTPPGGETLD QVKMRGIDFF EFLCQLILKE ADQKEQFSQG SPSNCLETSL AEIFPLGKNH SSKVNSDSGI PGLAASVLVV SHGAYMRSLF
Citations Bensaad K., et al. (2009) EMBO J. 28(19):3015-26.
Hasegawa H., et al. (2009) Leukemia. 23(11):2090-101.
NCBI NP_065108.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias TP53-induced glycolysis and apoptosis regulator
Similar products TIGAR, C12orf5, TP53-induced glycolysis and apoptosis regulator, ATGP0835-10ug, ATGP0835-20ug, ATGP0835-50ug, ATGP0835-100ug, ATGP0835-250ug, ATGP0835-500ug, ATGP0835-1mg, ATGP0835-10, ATGP0835-20, ATGP0835-50, ATGP0835-100, ATGP0835-250, ATGP0835-500, ATGP0835-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
32.6 kDa (294aa) confirmed by MALDI-TOF
Description
TIGAR, also known as TP53-induced glycolysis and apoptosis regulator, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. These facts indicate that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses. Recombinant human TIGAR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol
Antigen Species
Human
Gene Category
Apoptosis
Domain
1-270aa
Species of Protein
Human
Manufacturer - Search Terms
TIGAR, C12orf5, TP53-induced glycolysis and apoptosis regulator, ATGP0835-10ug, ATGP0835-20ug, ATGP0835-50ug, ATGP0835-100ug, ATGP0835-250ug, ATGP0835-500ug, ATGP0835-1mg, ATGP0835-10, ATGP0835-20, ATGP0835-50, ATGP0835-100, ATGP0835-250, ATGP0835-500, ATGP0835-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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