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Recombinant human Gremlin protein

ArtNr NKM-ATGP1961-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH MGS>KKKGSQG AIPPPDKAQH NDSEQTQSPQ QPGSRNRGRG QGRGTAMPGE EVLESSQEAL HVTERKYLKR DWCKTQPLKQ TIHEEGCNSR TIINRFCYGQ CNSFYIPRHI RKEEGSFQSC SFCKPKKFTT MMVTLNCPEL QPPTKKKRVT RVKQCRCISI DLD
Citations Helena Stabile, Stefania Mitola, et al. (2007). Blood 109:5 1834-1840.
NCBI NP_037504.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Gremlin-1 isoform 1,CKTSF1B1,DAND2,DRM,GREMLIN,IHG-2,PIG2
Similar products CKTSF1B1, DAND2, DRM, IHG-2, Gremlin, PIG2, GREMLIN, Gremlin-1 isoform 1, ATGP1961-10ug, ATGP1961-20ug, ATGP1961-50ug, ATGP1961-100ug, ATGP1961-250ug, ATGP1961-500ug, ATGP1961-1mg, ATGP1961-10, ATGP1961-20, ATGP1961-50, ATGP1961-100, ATGP1961-250, ATGP1961-500, ATGP1961-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Denatured
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
20.7 kDa (183aa)
Description
GREM1 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this protein belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this protein may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human GREM1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Antigen Species
Human
Gene Category
Signal Transduction
Domain
25-184aa
Species of Protein
Human
Manufacturer - Search Terms
Gremlin, Gremlin-1 isoform 1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2, PIG2, ATGP1961-10ug, ATGP1961-20ug, ATGP1961-50ug, ATGP1961-100ug, ATGP1961-250ug, ATGP1961-500ug, ATGP1961-1mg, ATGP1961-10, ATGP1961-20, ATGP1961-50, ATGP1961-100, ATGP1961-250, ATGP1961-500, ATGP1961-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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