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Recombinant human TDP-43/TARDBP protein

ArtNr NKM-ATGP2093-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence <MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGS>MSEY IRVTEDENDE PIEIPSEDDG TVLLSTVTAQ FPGACGLRYR NPVSQCMRGV RLVEGILHAP DAGWGNLVYV VNYPKDNKRK MDETDASSAV KVKRAVQKTS DLIVLGLPWK TTEQDLKEYF STFGEVLMVQ VKKDLKTGHS KGFGFVRFTE YETQVKVMSQ RHMIDGRWCD CKLPNSKQSQ DEPLRSRKVF
Citations Ou SH. et al. (1995) J Virol. 69:3584-3596.
Wang W, et al. The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. (Nat Med. 2016){https://pubmed.ncbi.nlm.nih.gov/27348499/}
Nielsen AK, et al. TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis. (Neurol Neuroimmunol Neuroinflamm. 2020){https://pubmed.ncbi.nlm.nih.gov/33361387/}
NCBI NP_031401.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias TAR DNA binding protein,ALS10,TDP43
Similar products TDP43, TARDBP, ALS10, TAR DNA binding protein, ATGP2093-10ug, ATGP2093-20ug, ATGP2093-50ug, ATGP2093-100ug, ATGP2093-250ug, ATGP2093-500ug, ATGP2093-1mg, ATGP2093-10, ATGP2093-20, ATGP2093-50, ATGP2093-100, ATGP2093-250, ATGP2093-500, ATGP2093-1
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Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Denatured
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
48.8 kDa (450aa)
Description
TARDBP, as known as TAR DNA binding protein, was originally identified as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It has also been identified in individuals diagnosed with chronic traumatic encephalopathy, a condition that often mimics ALS and that has been associated with athletes who have experienced multiple concussions and other types of head injury. It has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. Recombinant human TARDBP protein protein, fused to His-tag at N-terminus, was expressed in E. coli.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Antigen Species
Human
Gene Category
Epigenomics (Transcription & Translation)
Domain
1-414aa
Species of Protein
Human
Manufacturer - Search Terms
TDP43, TARDBP, TAR DNA binding protein, ALS10, TDP43, ATGP2093-10ug, ATGP2093-20ug, ATGP2093-50ug, ATGP2093-100ug, ATGP2093-250ug, ATGP2093-500ug, ATGP2093-1mg, ATGP2093-10, ATGP2093-20, ATGP2093-50, ATGP2093-100, ATGP2093-250, ATGP2093-500, ATGP2093-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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