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Recombinant human AIF protein

ArtNr NKM-ATGP2598-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH MGSEF>LGLTP EQKQKKAALS ASEGEEVPQD KAPSHVPFLL IGGGTAAFAA ARSIRARDPG ARVLIVSEDP ELPYMRPPLS KELWFSDDPN VTKTLRFKQW NGKERSIYFQ PPSFYVSAQD LPHIENGGVA VLTGKKVVQL DVRDNMVKLN DGSQITYEKC LIATGGTPRS LSAIDRAGAE VKSRTTLFRK IGDFRSLEKI SREVKSITII
Citations Zamzami N., et al. (1996) J Exp Med. 183: 1533-1544.
Susin S A., et al. (1996) J Exp Med. 184: 1331-1341.
NCBI NP_665811
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Apoptosis-inducing factor 1 mitochondrial isoform 2 precursor,Apoptosis-inducing factor 1,mitochondrial isoform 2 precursor,AIF,CMTX4,COWCK,COXPD6,PDCD8
Similar products AIF, PDCD8, Apoptosis-inducing factor 1, CMTX4, COWCK, COXPD6, mitochondrial isoform 2 precursor, Apoptosis-inducing factor 1 mitochondrial isoform 2 precursor, ATGP2598-10ug, ATGP2598-20ug, ATGP2598-50ug, ATGP2598-100ug, ATGP2598-250ug, ATGP2598-500ug, ATGP2598-1mg, ATGP2598-10, ATGP2598-20, ATGP2598-50, ATGP2598-100, ATGP2598-250, ATGP2598-500, ATGP2598-1
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Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
58.5 kDa (537aa)
Description
Apoptosis-inducing factor 1, mitochondrial isoform 2 precursor, also known as AIFM1, is a mitochondrial protein that translocates to the nucleus upon induction of apoptosis. AIFM1 has been shown to cause DNA fragmentation and chromatin condensation and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression has been shown to prevent the release of AIFM1 from mitochondria, but not to block its apoptogenic activity. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Recombinant human AIFM1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
Antigen Species
Human
Gene Category
Metabolism
Domain
98-609aa
Species of Protein
Human
Manufacturer - Search Terms
AIF, Apoptosis-inducing factor 1 mitochondrial isoform 2 precursor, Apoptosis-inducing factor 1, mitochondrial isoform 2 precursor, AIF, CMTX4, COWCK, COXPD6, PDCD8, ATGP2598-10ug, ATGP2598-20ug, ATGP2598-50ug, ATGP2598-100ug, ATGP2598-250ug, ATGP2598-500ug, ATGP2598-1mg, ATGP2598-10, ATGP2598-20, ATGP2598-50, ATGP2598-100, ATGP2598-250, ATGP2598-500, ATGP2598-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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