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Recombinant human FGF-21 (L174P) protein

ArtNr NKM-ATGP3789-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH> MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPAPPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Citations Dostalova I., et al. (2009) Physiol Res. 58(1):1-7
Kharitonenkov A., et al. (2008) BioDrugs. 22(1):37-44.
NCBI NP_061986
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Fibroblast growth factor 21
Similar products Fibroblast growth factor 21, FGF21 (L174P), ATGP3789-10ug, ATGP3789-20ug, ATGP3789-50ug, ATGP3789-100ug, ATGP3789-250ug, ATGP3789-500ug, ATGP3789-1mg, ATGP3789-10, ATGP3789-20, ATGP3789-50, ATGP3789-100, ATGP3789-250, ATGP3789-500, ATGP3789-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
21.6 kDa (202aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description
FGF-21 is a unique member of FGF super family that is reported to be primarily produced by the liver. FGF-21 has recently been shown to have beneficial effects on a variety of metabolic parameters, including glucose and lipid metabolism and insulin sensitivity in animal models and is thought to exert potent antidiabetic and lipid-lowering agent of obesity and type 2 diabetes mellitus. FGF-21 activity depends on membrane protein beta Klotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF-21 and activate downstream signaling pathways. Recombinant human FGF-21 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Antigen Species
Human
Gene Category
Hormones & Cytokines
Domain
29-209aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Species of Protein
Human
Manufacturer - Search Terms
FGF21 (L174P), Fibroblast growth factor 21, ATGP3789-10ug, ATGP3789-20ug, ATGP3789-50ug, ATGP3789-100ug, ATGP3789-250ug, ATGP3789-500ug, ATGP3789-1mg, ATGP3789-10, ATGP3789-20, ATGP3789-50, ATGP3789-100, ATGP3789-250, ATGP3789-500, ATGP3789-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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