Recombinant human BACE-1 protein

SDS-PAGE, Enzyme Activity

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

BACE-1, also known as beta-secretase 1 isoform A, is a member of aspartic protease and an integral membrane protein. It is involved in the proteolytic processing of the amyloid precursor protein (APP). This protein cleaves at the N-terminus of the A-beta peptide sequence of APP, and then leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has been implicated in the onset and/or progression of Alzheimer's disease. It is also distantly related to the pathogenic aspartic-acid protease plasmepsin, which is a potential target for future anti-malarial drugs. Recombinant human BACE-1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Enzymes & Proteases

< 1 EU per 1ug of protein (determined by LAL method)

Thr22

BACE1, ATGP3917-10ug, ATGP3917-20ug, ATGP3917-50ug, ATGP3917-100ug, ATGP3917-250ug, ATGP3917-500ug, ATGP3917-1mg, ATGP3917-10, ATGP3917-20, ATGP3917-50, ATGP3917-100, ATGP3917-250, ATGP3917-500, ATGP3917-1