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Recombinant mouse Thrombopoietin protein

ArtNr NKM-ATGP3930-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Mouse (Murine, Mus musculus)
Host HEK293
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKFPNRTSG LLETNFSVTA RTAGPGLLSR LQGFRVKITP GQLNQTSRSP VQISGYLNRT HG
Citations Jenkins JM., et al. (2007) Blood. 109:4739-4741.
Hitchcock IS., et al. (2014) Br J Haemato. 165:259-268.
NCBI NP_033405
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Thpo,C-mpl ligand,ML,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,MGDF,Myeloproliferative leukemia virus oncogene ligand,Mgdf,Ml,Mpllg,Tpo,thrombopoietin isoform 1
Similar products Thrombopoietin, ATGP3930-10ug, ATGP3930-20ug, ATGP3930-50ug, ATGP3930-100ug, ATGP3930-250ug, ATGP3930-500ug, ATGP3930-1mg, ATGP3930-10, ATGP3930-20, ATGP3930-50, ATGP3930-100, ATGP3930-250, ATGP3930-500, ATGP3930-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
36.4 kDa (341aa)
Description
Thrombopoietin(THPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Megakaryocytopoiesis is the cellular development process that leads to platelet production. It is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Recombinant mouse Thrombopoietin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by absorbance at 280nm)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Mouse
Gene Category
Cardiovascular
Domain
22-356aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range ≤4ng/ml.
Predicted nterm
Ser22
Species of Protein
Mouse
Manufacturer - Search Terms
Thrombopoietin, ATGP3930-10ug, ATGP3930-20ug, ATGP3930-50ug, ATGP3930-100ug, ATGP3930-250ug, ATGP3930-500ug, ATGP3930-1mg, ATGP3930-10, ATGP3930-20, ATGP3930-50, ATGP3930-100, ATGP3930-250, ATGP3930-500, ATGP3930-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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