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Recombinant human TIE2/TEK protein

ArtNr NKM-ATGP3947-50ug
Hersteller NKMAX
Menge 50 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host Baculovirus-Infected Insect Cells
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence AMDLILINSL PLVSDAETSL TCIASGWRPH EPITIGRDFE ALMNQHQDPL EVTQDVTREW AKKVVWKREK ASKINGAYFC EGRVRGEAIR IRTMKMRQQA SFLPATLTMT VDKGDNVNIS FKKVLIKEED AVIYKNGSFI HSVPRHEVPD ILEVHLPHAQ PQDAGVYSAR YIGGNLFTSA FTRLIVRRCE AQKWGPECNH LCTACMNNGV CHEDTGECIC PPGFMGRTCE KA
Citations Kitajima D., et al, (2016) J Cancer. 7:600-607.
Kelly-Goss MR., et al, (2017) Sci Rep. 7:9049.
NCBI NP_000450
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias TEK,TEK receptor tyrosine kinase,VMCM,venous malformations,multiple cutaneous and mucosal,TEK tyrosine kinase,endothelial,TIE2,TIE-2,VMCM1,CD202b,angiopoietin-1 receptor,Hyk,AA517024,STK1,p140 TEK
Lieferbar
Manufacturer - Type
Proteins
Manufacturer - Applications
SDS-PAGE, Bioactivity
Manufacturer - Category
Recombinant Protein
Manufacturer - Conjugate / Tag
hIgG-His-Tag
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
107.9 kDa (965aa)
Description
TEK, also known as angiopoietin-1 receptor isoform 1, is an endothelial cell-specific receptor tyrosine kinase subfamily (RTK). This protein acts as cell-surface receptor and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels and is required for normal angiogenesis and heart development during embryogenesis. Recombinant human TEK protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Human
Gene Category
Signal Transduction
Domain
23-748aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured by its binding ability in a functional ELISA with Human Angiopoietin-2 (CAT# ATGP3853). The ED50 range ≤1 ug/ml.
Additional Comment Only
ATGP3762 has been replaced with a catalog number ATGP3947.
Predicted nterm
Ala23
Species of Protein
Human
Manufacturer - Search Terms
Tie2, Angiopoietin-1 receptor isoform 1, TEK, CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1, ATGP3947-10ug, ATGP3947-20ug, ATGP3947-50ug, ATGP3947-100ug, ATGP3947-250ug, ATGP3947-500ug, ATGP3947-1mg, ATGP3947-010, ATGP3947-020, ATGP3947-050, ATGP3947-100, ATGP3947-250, ATGP3947-500, ATGP3947-01M, ATGP3762
Manufacturer - Similar Names
Tie2, Angiopoietin-1 receptor isoform 1, TEK, CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1, ATGP3947-10ug, ATGP3947-20ug, ATGP3947-50ug, ATGP3947-100ug, ATGP3947-250ug, ATGP3947-500ug, ATGP3947-1mg, ATGP3947-010, ATGP3947-020, ATGP3947-050, ATGP3947-100, ATGP3947-250, ATGP3947-500, ATGP3947-01M, ATGP3762

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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