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Recombinant human ACE-2 protein

ArtNr NKM-ATGP3963-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host HEK293
Konjugat/Tag HIS
Purity > 90% by SDS - PAGE
Sequence <DGS>QSTIEEQ AKTFLDKFNH EAEDLFYQSS LASWNYNTNI TEENVQNMNN AGDKWSAFLK EQSTLAQMYP LQEIQNLTVK LQLQALQQNG SSVLSEDKSK RLNTILNTMS TIYSTGKVCN PDNPQECLLL EPGLNEIMAN SLDYNERLWA WESWRSEVGK QLRPLYEEYV VLKNEMARAN HYEDYGDYWR GDYEVNGVDG YDYSRGQLIE DVEHTFEEIK PLYEHLHAYV
Citations Hamming I., et al, (2004) J Pathol. 203:631-637.
Mohammed A.r. Chamsi-Pasha., et al, (2014) Curr Heart Fail Rep. 11:58-63.
NCBI NP_068576.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Angiotensin-converting enzyme 2,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15,ACE2
Similar products ATGP3963-10ug, ATGP3963-20ug, ATGP3963-50ug, ATGP3963-100ug, ATGP3963-250ug, ATGP3963-500ug, ATGP3963-1mg, ATGP3963-10, ATGP3963-20, ATGP3963-50, ATGP3963-100, ATGP3963-250, ATGP3963-500, ATGP3963-1
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Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Enzyme Activity, Bioactivity
Manufacturer - Conjugate / Tag
hIgG-His-Tag
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
110.8kDa (965aa)
Description
ACE-2, also known as Angiotensin-converting enzyme 2, is an enzyme attached to the cell membranes of cells in the lungs, arteries, heart, kidney, and intestines. This enzyme lowers blood pressure by catalysing the hydrolysis of angiotensin II into angiotensin. It counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7) making it a promising drug target for treating cardiovascular diseases. ACE-2 also serves as the entry point into cells for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2. Recombinant human ACE-2, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques
Concentration
0.5mg/ml (determined by Absorbance at 280nm)
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Human
Gene Category
Virus
Domain
18-740aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured by its binding ability in a functional ELISA with SARS-CoV-2 Spike RBD. The ED50 range ≤ 100ng/ml. Specific activity is > 250 pmol/min/ug, and is defined as the amount of enzyme that hydrolysis 1.0 pmole of Mca-YVADAPK(Dnp)-OH per minute at pH 7.5, at 25C.
Predicted nterm
Asp
Species of Protein
Human
Manufacturer - Search Terms
, ATGP3963-10ug, ATGP3963-20ug, ATGP3963-50ug, ATGP3963-100ug, ATGP3963-250ug, ATGP3963-500ug, ATGP3963-1mg, ATGP3963-10, ATGP3963-20, ATGP3963-50, ATGP3963-100, ATGP3963-250, ATGP3963-500, ATGP3963-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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