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Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD protein

ArtNr NKM-ATGP3969-10ug
Hersteller NKMAX
Menge 10 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against SARS-CoV-2
Host HEK293
Konjugat/Tag HIS
Purity > 95% by SDS - PAGE
Sequence <DGSM>RVQPTE SIVRFPNITN LCPFGEVFNA TRFASVYAWN RKRISNCVAD YSVLYNSASF STFKCYGVSP TKLNDLCFTN VYADSFVIRG DEVRQIAPGQ TGKIADYNYK LPDDFTGCVI AWNSNNLDSK VGGNYNYLYR LFRKSNLKPF ERDISTEIYQ AGSTPCNGVE GFNCYFPLQS YGFQPTNGVG YQPYRVVVLS FELLHAPATV CGPKK<HHHHH H>
Citations Yushun Wan. et al. (2020) J Virol. 17:94:e00127-20.
Wu, F. et al. (2020) Nature. 579:265-269.
Ortega, J.T. et al. (2020) EXCLI J. 19:410-417.
Wanbo T., et al. (2020) Cell. Mol. Immunol. 17:613-620.
Gorbalenya A., et al. (2020) Nat. Microbiol. 5:536-544.
Tortorici, M.A. and D. Veesler. (2019). Adv. Virus Res. 105:93-116.
NCBI QHD43416.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Severe acute respiratory syndrome coronavirus 2,COVID-19,COVID-19 virus,COVID19,HCoV-19,Human coronavirus 2019,SARS-2,SARS-CoV2,SARS2,Wuhan coronavirus,SARS-CoV-2 SP RBD,2019-nCoV SP RBD,2019-nCoV,2019-nCoV,Spike RBD Protein
Similar products sars, covid, covid-19, covid19, sars2, Sars-CoV-2 S1, corona, corona virus, ATGP3969-10ug, ATGP3969-20ug, ATGP3969-50ug, ATGP3969-100ug, ATGP3969-250ug, ATGP3969-500ug, ATGP3969-1mg, ATGP3969-10, ATGP3969-20, ATGP3969-50, ATGP3969-100, ATGP3969-250, ATGP3969-500, ATGP3969-1
Lieferbar
Specificity SARS-CoV-2 (2019-nCoV)
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
24.9kDa(221aa)
Description
An epidemic of acute respiratory syndrome in humans, which appeared in Wuhan, China in December 2019, was caused by a novel coronavirus (SARS-CoV-2). This disease was named as "Coronavirus Disease 2019" (COVID-19). This virus shares highly homological sequence with SARS-CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV and MERS-CoV. The genome of this and other emerging pathogenic human CoVs encodes four major structural proteins [spike (S), envelope (E), membrane (M), and nucleocapsid (N)], approximately 16 nonstructural proteins (nsp1–16), and five to eight accessory proteins. Among them, the S protein plays an essential role in viral attachment, fusion, entry, and transmission. It comprises an N-terminal S1 subunit responsible for virus–receptor binding and a C-terminal S2 subunit responsible for virus–cell membrane fusion. S1 is further divided into an N-terminal domain (NTD) and a receptor-binding domain (RBD). SARS-CoV-2 and SARS-CoV bind angiotensin-converting enzyme 2 (ACE2) while MERS-CoV binds dipeptidyl peptidase 4 (DPP4), as receptors on the host cell expressing ACE2 (e.g., pneumocytes, enterocytes) or DPP4 (e.g., liver or lung cells including Huh-7, MRC-5, and Calu-3). During infection, CoV first binds the host cell through interaction between its S1-RBD and the cell membrane receptor, triggering conformational changes in the S2 subunit that result in virus fusion and entry into the target cell. Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Concentration
0.25mg/ml (determined by Absorbance at 280nm)
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
SARS-CoV-2 (2019-nCoV)
Gene Category
Virus
Domain
319-529aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured by its binding ability in a functional ELISA with Human ACE-2 (CAT# ATGP3963)
Predicted nterm
Asp
Species of Protein
SARS-CoV-2 (2019-nCoV)
Manufacturer - Search Terms
covid-19, covid19, sars, sars2, corona virus, Sars-CoV-2 S1, covid, corona, ATGP3969-10ug, ATGP3969-20ug, ATGP3969-50ug, ATGP3969-100ug, ATGP3969-250ug, ATGP3969-500ug, ATGP3969-1mg, ATGP3969-10, ATGP3969-20, ATGP3969-50, ATGP3969-100, ATGP3969-250, ATGP3969-500, ATGP3969-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug
Lieferbar: In stock
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