Recombinant human CEACAM-8/CD66b protein

QLTIEAVPSN AAEGKEVLLL VHNLPQDPRG YNWYKGETVD ANRRIIGYVI SNQQITPGPA YSNRETIYPN ASLLMRNVTR NDTGSYTLQV IKLNLMSEEV TGQFSVHPET PKPSISSNNS NPVEDKDAVA FTCEPETQNT TYLWWVNGQS LPVSPRLQLS NGNRTLTLLS VTRNDVGPYE CEIQNPASAN FSDPVTLNVL YGPDAPTISP SDTYYHAGVN LNLSCHAASN PPSQYSWSVN GTFQQYTQKL FIPNITTKNS GSYACHTTNS ATGRNRTTVR MITVSD

CEACAM-8, also known as CD66b, is a cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. It mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Its main function is cell adhesion, cell migration, and pathogen binding. However, its biological functions are largely unknown in eosinophils. It has been reported that CEACAM-8 is highly expressed on the surface of human peripheral blood eosinophils isolated from healthy individuals and used as granulocyte marker. Recombinant human CEACAM-8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

< 1 EU per 1ug of protein (determined by LAL method)

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Kuroki M., et al, (2001) J Leukoc Biol. 70:543-550.; ; Ilie M., et al, (2012) Cancer. 118:1726-1737.; ; Posabella A, et al, (2020) J Cancer Res Clin Oncol. 146:127-136.; ;

Gln 35