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Recombinant SARS-CoV S1 Subunit protein

ArtNr NKM-ATGP4012-10ug
Hersteller NKMAX
Menge 10 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Coronavirus
Host HEK293
Konjugat/Tag HIS
Purity > 90% by SDS - PAGE
Sequence SDLDRCTTFD DVQAPNYTQH TSSMRGVYYP DEIFRSDTLY LTQDLFLPFY SNVTGFHTIN HTFGNPVIPF KDGIYFAATE KSNVVRGWVF GSTMNNKSQS VIIINNSTNV VIRACNFELC DNPFFAVSKP MGTQTHTMIF DNAFNCTFEY ISDAFSLDVS EKSGNFKHLR EFVFKNKDGF LYVYKGYQPI DVVRDLPSGF NTLKPIFKLP LGINITNFRA ILTAFSPAQD IW
Citations Kukla M., et al, (2020) J Clin Med. 9:1420.
Ayouba A., et al,(2020) J Clin Virol. 129:104521.
Tortorici, M.A. and D. Veesler (2019). Adv. Virus Res. 105:93-116.
Li F, et al, (2005) Science. 309:1864-1868.
Struck AW, et al, (2012) Antiviral Res. 94:288-296.
NCBI NP_828851.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias E2 glycoprotein precursor,Spike glycoprotein,S glycoprotein,E2,Peplomer protein,Severe acute repiratory Syndrome-related Coronavirus,SARS,SRAS-CoV,SARS-CoV1,spike protein S1
Similar products ATGP4012-10ug, ATGP4012-20ug, ATGP4012-50ug, ATGP4012-100ug, ATGP4012-250ug, ATGP4012-500ug, ATGP4012-1mg, ATGP4012-10, ATGP4012-20, ATGP4012-50, ATGP4012-100, ATGP4012-250, ATGP4012-500, ATGP4012-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
73.7kDa(660aa)
Description
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and the recently identified novel Coronavirus (SARS-CoV-2) belong to the Coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks. SARS-CoV emerged in 2003 as a significant threat to human health. SARS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. It attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. A metallopeptidase, angiotensin-converting enzyme 2 (ACE-2), has been identified as a functional receptor for SARS-CoV through interaction with a receptor binding domain (RBD) located at the C-terminus of S1 subunit. Recombinant SARS-CoV spike S1 subunit fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Concentration
0.25mg/ml (determined by Absorbance at 280nm)
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
SARS-CoV
Gene Category
Virus
Domain
14-667aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured by its binding ability in a functional ELISA with Human ACE-2 (CAT# ATGP3963)
Predicted nterm
Ser14
Species of Protein
SARS-CoV
Manufacturer - Search Terms
ATGP4012-10ug, ATGP4012-20ug, ATGP4012-50ug, ATGP4012-100ug, ATGP4012-250ug, ATGP4012-500ug, ATGP4012-1mg, ATGP4012-10, ATGP4012-20, ATGP4012-50, ATGP4012-100, ATGP4012-250, ATGP4012-500, ATGP4012-1, ATGP4012-10ug, ATGP4012-20ug, ATGP4012-50ug, ATGP4012-100ug, ATGP4012-250ug, ATGP4012-500ug, ATGP4012-1mg, ATGP4012-10, ATGP4012-20, ATGP4012-50, ATGP4012-100, ATGP4012-250, ATGP4012-500, ATGP4012-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug
Lieferbar: In stock
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