Recombinant human FIH-1/HIF-1AN protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes. Recombinant human HIF1AN protein was expressed in E. coli and purified by using conventional chromatography techniques.

Liquid in. 20mM Tris-HCl buffer (pH 8.0)

Cell Cycle

Human

Hypoxia-inducible factor 1 alpha subunit inhibitor, Hypoxia-inducible factor asparagine hydroxylase, Factor inhibiting HIF-1, FIH1, Hypoxia-inducible factor 1, alpha subunit inhibitor Hypoxia inducible factor asparagine hydroxylase, Factor inhibiting HIF1, FIH 1, FLJ20615, FLJ22027, Hypoxia inducible factor 1 alpha inhibitor, Hypoxia inducible factor 1 alpha subunit inhibitor, Peptide aspartate beta dioxygenase, DKFZp762F1811, Hypoxia-Inducible Factor-1 Alpha Inhibitor