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Recombinant human Leptin/OB protein

ArtNr NKM-LEP3002-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC
Citations Jeong KJ., et al. (1999) Appl Environ Microbiol. 65(7), 3027-32.
Anini Y., et al. (2003) Diabetes. 52(2), 252-259.
Hyogo H., et al. (2002) J. Biol. Chem. 277(37), 34117-34124.

Lee EN, et al. Stabilizing peptide fusion for solving the stability and solubility problems of therapeutic proteins. Pharm Res. 2005 Oct;22(10):1735-46.{https://pubmed.ncbi.nlm.nih.gov/16180132/}
NCBI NP_000221
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias LEP,OB,OBS,Leptin,Obesity factor,Obese protein,Leptin,Leptin Murine Obesity Homolog,Leptin Precursor Obesity Factor,Obesity,Obesity homolog mouse,Obesity Murine Homolog Leptin
Similar products Leptin, LEP, OB, OBS, Obese protein, Obesity factor, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, Obesity, Obesity homolog mouse, Obesity Murine Homolog Leptin, LEP3002-10ug, LEP3002-20ug, LEP3002-50ug, LEP3002-100ug, LEP3002-250ug, LEP3002-500ug, LEP3002-1mg, LEP3002-10, LEP3002-20, LEP3002-50, LEP3002-100, LEP3002-250, LEP3002-500, LEP3002-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
16 kDa (147aa) confirmed by MALDI-TOF
Description
Human leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation. Recombinant human leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Antigen Species
Human
Gene Category
Hormones & Cytokines
Domain
22-167aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Species of Protein
Human
Manufacturer - Search Terms
Leptin, OB, LEP, OB, OBS, Leptin, Obesity factor, Obese protein, Leptin, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, Obesity, Obesity homolog mouse, Obesity Murine Homolog Leptin, LEP3002-10ug, LEP3002-20ug, LEP3002-50ug, LEP3002-100ug, LEP3002-250ug, LEP3002-500ug, LEP3002-1mg, LEP3002-10, LEP3002-20, LEP3002-50, LEP3002-100, LEP3002-250, LEP3002-500, LEP3002-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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