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Recombinant human PRMT1 protein

ArtNr NKM-PRM0802-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag MBP, HIS
Purity > 90% by SDS-PAGE
Sequence <MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET A
Citations Goulet I., et al. (2007) J Biol Chem. 282(45):33009-21.
Tang J., et al. (2000) J Biol Chem. 275(11):7723-30.

Yamaguchi A, et al. The Effect of PRMT1-Mediated Arginine Methylation on the Subcellular Localization, Stress Granules, and Detergent-Insoluble Aggregates of FUS/TLS. (PLoS One. 2012){https://pubmed.ncbi.nlm.nih.gov/23152885/}
Ryan VH, et al. Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation. (Mol Cell. 2018){https://pubmed.ncbi.nlm.nih.gov/29358076/}
Dong R, et al. The translation initiating factor eIF4E and arginine methylation underlie G3BP1 function in dendritic spine development of neurons. (J Biol Chem. 2023){https://pubmed.ncbi.nlm.nih.gov/37442236/}
NCBI NP_938074.2
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Protein arginine N-methyltransferase 1 isoform 3,HRMT1L2,HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae),HCP1,ANM1,Histone-arginine N-methyltransferase PRMT1,Interferon receptor 1-bound protein 4,IR1B4,ANM1,highly conserved protein 1
Similar products PRMT1, HMT2, HRMT1L2, IR1B4, HCP1, ANM1, protein arginine methyltransferase 1, HCP 1, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, Heterogeneous nuclear ribonucleoproteins methyltransferase like2, HMT 2, HMT1 hnRNP methyltransferase, HMT1 hnRNP methyltransferase like 2, HRMT1 L2, HRMT1L 2, Human mRNA for suppressor for yeast mutant, Human mRNA for suppressor for yeast mutant complete cds, Interferon receptor 1 bound protein 4, Interferon receptor 1 bound protein4, Interferon receptor 1bound protein 4, IR1 B4, IR1B 4, Mrmt 1, Mrmt1, PRMT 1, Protein arginine N methyltransferase 1, Protein arginine N methyltransferase1, S. cerevisiae like 2, PRMT1 isoform3, HMT1 hnRNP methyltransferase-like 2 isoform 3 ANM 1, HMT1 hnRNP methyltransferase-like 2 isoform 3, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae), HMT1 (hnRNP methyltransferase S. cerevisiae) like 2, PRM0802-10ug, PRM0802-20ug, PRM0802-50ug, PRM0802-100ug, PRM0802-250ug, PRM0802-500ug, PRM0802-1mg, PRM0802-0
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Enzyme Activity
Manufacturer - Conjugate / Tag
His-MBP-Tag
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
84.2 kDa (750aa)
Description
Protein arginine N-methyltransferase 1 (PRMT1) is a type I methyltransferase that transfers a methyl group from S-adenosylmethionine to guanidino nitrogens of arginine residues to form monomethylarginine and asymmetric dimethylarginine. Functions of type I arginine methylation in proteins may include regulation of transcription, modulation of the affinity of nucleic acid-binding proteins, regulation of interferon signaling pathways, and targeting of nuclear proteins. Recombinant human PRMT1, fused to His-MBP tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 40mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 4mM MgCl₂, 2mM DTT, 40% glycerol
Antigen Species
Human
Gene Category
Histone Related
Domain
1-353aa
Bioactivity Comment Only
Specific activity is > 10 nmol/min/mg, and is defined as the amount of enzyme that transfer 1.0 nmole of methyl group on histone H4 per minute at 37C.
Species of Protein
Human
Manufacturer - Search Terms
S. cerevisiae like 2, Protein arginine N methyltransferase1, Protein arginine N methyltransferase 1, protein arginine methyltransferase 1, PRMT1 isoform3, PRMT1, PRMT 1, Mrmt1, Mrmt 1, IR1B4, IR1B 4, IR1 B4, Interferon receptor 1bound protein 4, Interferon receptor 1 bound protein4, Interferon receptor 1 bound protein 4, Human mRNA for suppressor for yeast mutant complete cds, Human mRNA for suppressor for yeast mutant, HRMT1L2, HRMT1L 2, HRMT1 L2, HMT2, HMT1 hnRNP methyltransferase-like 2 isoform 3 ANM 1, HMT1 hnRNP methyltransferase-like 2 isoform 3, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae), HMT1 hnRNP methyltransferase like 2, HMT1 hnRNP methyltransferase, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2, HMT 2, Heterogeneous nuclear ribonucleoproteins methyltransferase like2, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, HCP1, HCP 1, ANM1, PRM0802-10ug, PRM0802-20ug, PRM0802-50ug, PRM0802-100ug, PRM0802-250ug, PRM0802-500ug, PRM0802-1mg, PRM0802-0

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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