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Recombinant human alpha-Synuclein protein

ArtNr NKM-SNA2001-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 1 mg 20 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Citations Jakes, R., et al. (1994) FEBS lett. 345, 27-32
ueda, K., et al. (1993) Proc. Natl. Acad. Sci. uSA 90, 11282-11286
Kim, J. (1997) Molecules and Cells 7, 78-83
Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334.

Sung JY, et al. Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases. (J Biol Chem. 2005){https://pubmed.ncbi.nlm.nih.gov/15863497/}
Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006){https://pubmed.ncbi.nlm.nih.gov/16524375/}
Kim EJ, et al. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. (J Biol Chem. 2006){https://pubmed.ncbi.nlm.nih.gov/16959772/}
Lee HJ, et al. Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. (Int J Biochem Cell Biol. 2008){https://pubmed.ncbi.nlm.nih.gov/18291704/}
Lee HJ, et al. Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. (Biochem Biophys Res Commun. 2008){https://pubmed.ncbi.nlm.nih.gov/18492487/}
Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/}
Lee HJ, et al. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. (J Biol Chem. 2010){https://pubmed.ncbi.nlm.nih.gov/20071342/}
Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010){https://pubmed.ncbi.nlm.nih.gov/20448034/}
Lee HJ, et al. Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities. (J Neurosci Methods. 2011){https://pubmed.ncbi.nlm.nih.gov/21658411/}
Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011){https://pubmed.ncbi.nlm.nih.gov/21985244/}
Kim KS, et al. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. (J Biol Chem. 2012){https://pubmed.ncbi.nlm.nih.gov/22619171/}
Rodriguez-Araujo G, et al. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. (Cell Mol Life Sci. 2013){https://pubmed.ncbi.nlm.nih.gov/23124190/}
Kim JY, et al. Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway. (Neural Regen Res. 2013){https://pubmed.ncbi.nlm.nih.gov/25206648/}
Kim HL, et al. The Presence of Outer Arm Fucose Residues on the N-Glycans of Tissue Inhibitor of Metalloproteinases-1 Reduces Its Activity. (J Proteome Res. 2014){https://pubmed.ncbi.nlm.nih.gov/23815085/}
Rodriguez-Araujo G, et al. Low alpha-synuclein levels in the blood are associated with insulin resistance. (Sci Rep. 2015){https://pubmed.ncbi.nlm.nih.gov/26159928/}
Takami Y, et al. Novel pathophysiological roles of α-synuclein in age-related vascular endothelial dysfunction. (FASEB J. 2022){https://pubmed.ncbi.nlm.nih.gov/26159928/}
NCBI NP_000336.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias SNCA,NACP,PARK1,PARK4,PD1,α-synuclein Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,Parkinson disease 4,autosomal dominant Lewy body
Similar products Alpha synuclein, alpha-Synuclein, SNCA, NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PD1, MGC110988, PARK4, Synuclein alpha, alphaSYN, MGC105443, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, PARK 4, Parkinson disease familial 1, PD 1, a-Synuclein, Alpha-synuclein isoform NACP140, precursor of PARK 1, SNA2001-10ug, SNA2001-20ug, SNA2001-50ug, SNA2001-100ug, SNA2001-250ug, SNA2001-500ug, SNA2001-1mg, SNA2001-10, SNA2001-20, SNA2001-50, SNA2001-100, SNA2001-250, SNA2001-500, SNA2001-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
14.4 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description
alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
Concentration
1mg/ml (determined by BCA assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl, 1mM MgCl2
Antigen Species
Human
Gene Category
Neuroscience
Domain
1-140aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Species of Protein
Human
Manufacturer - Search Terms
a-Synuclein, SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, SNA2001-10ug, SNA2001-20ug, SNA2001-50ug, SNA2001-100ug, SNA2001-250ug, SNA2001-500ug, SNA2001-1mg, SNA2001-10, SNA2001-20, SNA2001-50, SNA2001-100, SNA2001-250, SNA2001-500, SNA2001-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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