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Recombinant human alpha-Synuclein (lyophilized) protein

ArtNr NKM-SNA2001L-20ug
Hersteller NKMAX
Menge 20 ug
Quantity options 100 ug 1 mg 20 ug
Kategorie
Typ Proteins Recombinant
Format Lyophilized
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Citations Jakes, R., et al. (1994) FEBS lett. 345, 27-32
ueda, K., et al. (1993) Proc. Natl. Acad. Sci. uSA 90, 11282-11286
Kim, J. (1997) Molecules and Cells 7, 78-83
Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334.

Rodriguez-Araujo G, et al. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. (Cell Mol Life Sci. 2013){https://pubmed.ncbi.nlm.nih.gov/23124190/}
Kim JY, et al. Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway. (Neural Regen Res. 2013){https://pubmed.ncbi.nlm.nih.gov/25206648/}
Kim HL, et al. The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity. (J Proteome Res. 2013){https://pubmed.ncbi.nlm.nih.gov/23815085/}
Rodriguez-Araujo G, et al. Low alpha-synuclein levels in the blood are associated with insulin resistance. (Sci Rep. 2015){https://pubmed.ncbi.nlm.nih.gov/26159928/}
Takami Y, et al. Novel pathophysiological roles of α-synuclein in age-related vascular endothelial dysfunction. (FASEB J. 2022){https://pubmed.ncbi.nlm.nih.gov/36125010/}
Lu J, et al. A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinsons disease. (J Neuroinflammation. 2022){https://pubmed.ncbi.nlm.nih.gov/35599331/}
Wang D, et al. Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming. (Acta Pharm Sin B. 2023){https://pubmed.ncbi.nlm.nih.gov/36873190/}
Lee J, et al. Targeted degradation of ⍺-synuclein aggregates in Parkinsons disease using the AUTOTAC technology. (Mol Neurodegener. 2023){https://pubmed.ncbi.nlm.nih.gov/37355598/}
NCBI NP_000336
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias SNCA,NACP,PARK1,PARK4,PD1,α-synuclein Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,Parkinson disease 4,autosomal dominant Lewy body
Similar products Alpha synuclein, alpha-Synuclein, SNCA, NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PD1, MGC110988, PARK4, Synuclein alpha, alphaSYN, MGC105443, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, PARK 4, Parkinson disease familial 1, PD 1, Alpha-synuclein isoform NACP140, precursor of PARK 1, a-Synuclein (lyophilized), SNA2001L-10ug, SNA2001L-20ug, SNA2001L-50ug, SNA2001L-100ug, SNA2001L-250ug, SNA2001L-500ug, SNA2001L-1mg, SNA2001L-10, SNA2001L-20, SNA2001L-50, SNA2001L-100, SNA2001L-250, SNA2001L-500, SNA2001L-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
14.4 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description
alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
Concentration
Reconstitute in sterile distilled water at a concentration of 1mg/ml or less.
Formulation
Lyophilized from a 0.2 um filtered in 20mM Tris-HCl buffer (pH 7.5) containing 100mM NaCl, 1mM MgCl2
Antigen Species
Human
Gene Category
Neuroscience
Domain
1-140aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Species of Protein
Human
Manufacturer - Search Terms
a-Synuclein (lyophilized), SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, SNA2001L-10ug, SNA2001L-20ug, SNA2001L-50ug, SNA2001L-100ug, SNA2001L-250ug, SNA2001L-500ug, SNA2001L-1mg, SNA2001L-10, SNA2001L-20, SNA2001L-50, SNA2001L-100, SNA2001L-250, SNA2001L-500, SNA2001L-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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