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Recombinant human alpha-Synuclein (A53T) protein

Recombinant human alpha-Synuclein (A53T) protein

ArtNr	NKM-SNA2002-20ug
Hersteller	NKMAX
Menge	20 ug
Quantity options	100 ug 20 ug 500 ug
Kategorie	Oncology Neuroscience Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Infectious Diseases Viral Infections Coronavirus (COVID-19) By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Adenocarcinoma Autophagy SDS-PAGE
Typ	Proteins Recombinant
Format	Liquid
Applikationen	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Konjugat/Tag	Untagged
Purity	> 95% by SDS-PAGE
Sequence	MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Citations	Polymeropoulos MH., et al. (1997) Science. 276, 2045-7. Park, SM. et al. (2002) Blood. 100(7),2506-2514 Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008){https://pubmed.ncbi.nlm.nih.gov/18449945/} Kim KS, et al. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. (J Biol Chem. 2012){https://pubmed.ncbi.nlm.nih.gov/22619171/} Konno M, et al. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012){https://pubmed.ncbi.nlm.nih.gov/22892036/}
NCBI	NP_000336.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SNCA,NACP,PARK1,PARK4,PD1,α-synuclein Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,Parkinson disease 4,autosomal dominant Lewy body
Similar products	Alpha synuclein, alpha-Synuclein, SNCA, NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PD1, MGC110988, PARK4, Synuclein alpha, alphaSYN, MGC105443, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, PARK 4, Parkinson disease familial 1, PD 1, Alpha-synuclein isoform NACP140, precursor of PARK 1, a-Synuclein (A53T), SNA2002-10ug, SNA2002-20ug, SNA2002-50ug, SNA2002-100ug, SNA2002-250ug, SNA2002-500ug, SNA2002-1mg, SNA2002-10, SNA2002-20, SNA2002-50, SNA2002-100, SNA2002-250, SNA2002-500, SNA2002-1
Lieferbar
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	14.4 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description	A Parkinson's disease-related point mutant (A53T) of alpha-synuclein. A53T mutant of alpha-synuclein was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl
Antigen Species	Human
Gene Category	Neuroscience
Domain	1-140aa
Species of Protein	Human
Manufacturer - Search Terms	a-Synuclein (A53T), SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, SNA2002-10ug, SNA2002-20ug, SNA2002-50ug, SNA2002-100ug, SNA2002-250ug, SNA2002-500ug, SNA2002-1mg, SNA2002-10, SNA2002-20, SNA2002-50, SNA2002-100, SNA2002-250, SNA2002-500, SNA2002-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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NKM-SNA2002-20ug-datasheet.pdf

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Menge: 20 ug

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Lieferung vsl. bis 31.07.2025

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