Cysteine-Rich Secretory Protein 2/CRISP2

Ambient

Recombinant Human Cysteine-Rich Secretory Protein 2/CRISP2 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Lys22-Tyr243) of Human CRISP2 fused with a polyhistidine tag at the C-terminus.

Cysteine-Rich Secretory Protein 2 (CRISP2) is a member of the CRISP subdivision of the CAP superfamily, which is defined by a CAP signature motif common to the entire superfamily, & has been localized to both the sperm acrosome & tail. Within mammals, four CRISPs have been defined: CRISP1 (acidic epididymal glycoprotein [AEG], proteins D & E), CRISP2 (TPX1), CRISP3, & CRISP4. All are strongly expressed within the male reproductive tract, suggesting key roles in male fertility. CRISP2 may regulate some ion channels' activity & therebye regulate calcium fluxes during sperm capacitation.