Recombinant Human Interleukin-4/IL-4 (Human Cells)

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Recombinant Human Interleukin-4 is produced by our Mammalian expression system & the target gene encoding His25-Ser153 is expressed.

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T & B cell responses including cell proliferation, survival & gene expression. IL-4 is produced by mast cells, T cells, & bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, & IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 & IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production & allergic response.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.