Recombinant Human CD44/MIC4 (C-Fc)

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Recombinant Human CD44 is produced by our Mammalian expression system & the target gene encoding Gln21-Pro220 is expressed with a Fc tag at the C-terminus.

CD44 is a cell-surface receptor for hyaluronic acid & also interacts with other ligands, such as osteopontin, collagens, & matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T & monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages & participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.