[Novoprotein] Recombinant Human 2'-5'-Oligoadenylate Synthase-Like Protein/OASLOASL (C-6His)

Store at < -20C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Recombinant Human OASL is produced by our E.coli expression system & the target gene encoding Met1-His100 is expressed with a 6His tag at the C-terminus.

2'-5'-oligoadenylate synthase-like protein (OASL) contains 2 ubiquitin-like domains, & belongs to the 2-5A synthase family. The ubiquitin-like domains are essential for its antiviral activity. OASL can be induced by type I interferon (IFN) & viruses, & expressed in most tissues such as primary blood Leukocytes & other hematopoietic system tissues, colon, stomach & to some extent in testis. OASL can specifically interacts with the ligand binding domain of the thyroid receptor (TR) without the presence of thyroid hormone. It does not have 2'-5'-OAS activity, but can bind double-stranded RNA. It also displays antiviral activity against encephalomyocarditis virus (EMCV) & hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.