Recombinant Human 17beta-Hydroxysteroid Dehydrogenase 10/HSD17B10 (C-6His)

Store at < -20C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Recombinant Human HSD17B10 is produced by our Mammalian expression system & the target gene encoding Met1-Pro261 is expressed with a 6His tag at the C-terminus.

3-hydroxyacyl-CoA dehydrogenase type-2(HSD17B10) belongs to the short-chain dehydrogenases/reductases (SDR) family. HSD17B10 is ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. It functions in mitochondrial tRNA maturation. It catalyzes the beta-oxidation at position 17 of androgens & estrogens & has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. It also catalyzes the third step in the beta-oxidation of fatty acids & carries out oxidative conversions of 7-alpha-OH & 7-beta-OH bile acids. The protein exhibits 20-beta-OH & 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, HSD17B10 may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.