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Human PD-L1 / B7-H1 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified) Europäischer Partner

ArtNr PDL-H5250-100ug
Hersteller ACROBiosystems
Menge 100 ug
Quantity options 100 ug 1 mg
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Konjugat/Tag Unconjugated
Purity 95%
Citations (1) Dong H., et al., 1999, Nat. Med. 5:1365-1369. (2) Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034. (3) Nishimura H., et al., 2001, Trends in Immunology 22:265.
NCBI NP 054862.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / Immune Checkpoint Proteins
Manufacturer - Conjugate / Tag
C-LlamaFc(LlamaIgG2b), Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
53.0 kDa
Manufacturer - Format
Powder
Description
Human PD-L1 Protein, Llama IgG2b Fc Tag (PDL-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 19- Arg 238 (Accession # Q9NZQ7-1).
Background
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1, which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Molecule
PD-L1
Exp Region
Phe 19- Arg 238
Characteristics
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 53.0 kDa. The protein migrates as 65-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.01 EU per μg
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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