Soluble TNF Receptor Type II Recombinant Protein

Recombinant Proteins

The lyophilized Soluble TNF Receptor Type II recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Soluble TNF Receptor Type II is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Soluble TNF Receptor Type II recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β . Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein.

4507577

Homo sapiens

Human