IL-2 Recombinant Protein

This recombinant proteins is for research use only.

Stable for at least 1 year after receipt when stored at -80˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

~14kDa (SDS-PAGE)

Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.

NP_000577.2

IL2

Homo sapiens

Measured in a cell proliferation assay using CTLL2 cells. The ED50 for this effect is typically 0.35-1.4ng/ml.