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Mouse Siglec-10 Protein, His Tag

Mouse Siglec-10 Protein, His Tag

ArtNr	SI0-M52H7-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 200 ug x 5
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293
Konjugat/Tag	Unconjugated
Purity	90%
Citations	(1) Whitney G., et al. 2001, Eur J Biochem., 268(23), 6083-96. (2) Kivi E., et al. 2009, Blood., 114(26), 5385-92. (3) Munday J., et al. 2001, Biochem J., 355(Pt 2), 489-97.
NCBI	NP_766488.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10xHis, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	60.7 kDa
Manufacturer - Format	Powder
Description	The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Background	The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Molecule	Siglec-10
Exp Region	Gln 18 - Lys 543
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.7 kDa. The protein migrates as 40 kDa, 50 kDa and 75-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	25 mM MES, 150 mM NaCl, pH5.5
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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SI0-M52H7-100ug-datasheet.pdf

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