Biotinylated Human TLR3 Protein (Primary Amine Labeling) (TLR-HM103B)

TLR3

Shipped with dry ice.

The protein has a predicted MW of 78.7 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result.

TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.

Supplied as 0.22μm filtered solution in PBS (pH 7.4).