DYRK1A, Recombinant, Human, aa159-479, His-Tag (Dual-Specificity Tyrosine-(Y)- Phosphorylation Regulated Kinase 1A, Dual Specificity Yak1-Related Kinase, Dyrk, PSK47)

Blue Ice

39, 4

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.4M urea, 10% glycerol.

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidin6e repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development.

Source:
Recombinant protein corresponding to aa159-479 from human DYRK1A, fused to His-tag at N-terminus, expressed in E.coli.

Molecular Weight:
~39.4kD (343aa)

Applications:
Suitable for use in SDS-PAGE. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.