RAD50 Antibody

Blue Ice

Observed: 180kDa

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

None

NIH3T3

A-549

Mouse lung

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

A synthetic peptide of human RAD50

RAD50 homolog (S. cerevisiae)

Optimal dilutions for each application to be determined by the researcher.