NF2 Antibody, KO Validated

Blue Ice

Observed: 80kDa

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

KO

Affinity purification

A549

HeLa

Mouse kidney

batch dependent

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Polyclonal

Homo sapiens

Antibody is Knockout validated.