ALK Antibody

ArtNr	PRS-13-278-100uL
Hersteller	ProSci
Menge	100 uL
Quantity options	100 uL
Format	Liquid
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
NCBI	ALK
Alias	CD246, NBLST3
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Specificity	Human,Mouse
Shipping Temperature	Blue Ice
Storage Conditions	Store at 4°C. Avoid freeze / thaw cycles.
Molecular Weight	Observed: 185kDa
Manufacturer - Research Area	Cancer, Cell Cycle, Growth Factors, Immunology, Neuroscience, Signal Transduction
Background	This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
Purification	Affinity purification
Concentration	Batch dependent
Buffer	PBS with 0.02% sodium azide, pH7.3.
Application Note	WB: 1:500 - 1:1000 IHC: 1:50 - 1:100
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human ALK (NP_004295.2).
Clonality	Polyclonal
NCBI Organism	Homo sapiens

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Menge: 100 uL

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Lieferung vsl. bis 02.10.2025