ROCK1 Antibody, KO Validated

Blue Ice

Observed: 158kDa

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

KO

Affinity purification

293T

Jurkat

batch dependent

WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
IP: 1:50 - 1:100

Polyclonal

Homo sapiens

Antibody is Knockout validated.