UPF1 Antibody

Blue Ice

Observed: 130kDa

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

None

293T

K-562

Mouse liver

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

A synthetic peptide corresponding to a sequence within amino acids 270-370 of human UPF1 (NP_002902.2).

UPF1 regulator of nonsense transcripts homolog (yeast)

Optimal dilutions for each application to be determined by the researcher.