HMGCR Antibody

ArtNr	PRS-16-554-100uL
Hersteller	ProSci
Menge	100 uL
Quantity options	100 uL
Kategorie	Metabolism Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Western Blot Enzymes Fatty Acid Synthesis Primary Antibodies
Typ	Antibody Primary
Format	Liquid
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
NCBI	HMGCR
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	HMG-CoA reductase,hydroxymethylglutaryl-CoA reductase,3-hydroxy-3-methylglutaryl CoA reductase (NADPH),LDLCQ3,3-hydroxy-3-methylglutaryl-Coenzyme A reductase,HMGCR
Versandbedingung	Gekühlt
Lieferbar
Specificity	Human,Mouse,Rat
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Store at -20˚ C. Avoid freeze / thaw cycles.
Molecular Weight	Observed: 110kDa
Manufacturer - Research Area	Cancer, Signal Transduction
Background	HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
By Type	Cancer, Signal Transduction
Modifications	None
Purification	Affinity purification
Positive Control 1	HepG2
Positive Control 2	HeLa
Positive Control 3	SH-SY5Y
Positive Control 4	BT-474
Positive Control 5	Mouse spleen
Positive Control 6	Rat liver
Concentration	batch dependent
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Note	WB: 1:1000 - 1:4000IHC: 1:50 - 1:100
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1).
Clonality	Polyclonal
NCBI Official Name	3-hydroxy-3-methylglutaryl-CoA reductase
NCBI Organism	Homo sapiens
User Note	Optimal dilutions for each application to be determined by the researcher.

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Menge: 100 uL

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Lieferung vsl. bis 01.01.2026