FADD Antibody, KO Validated

Blue Ice

Observed: 28kDa

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

KO

Affinity purification

HeLa

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Recombinant protein of human FADD

Fas (TNFRSF6)-associated via death domain

Optimal dilutions for each application to be determined by the researcher.