MCM10 Antibody

ArtNr	PRS-22-776-100uL
Hersteller	ProSci
Menge	100 uL
Quantity options	100 uL
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
NCBI	MCM10
Alias	CNA43, DNA43, PRO2249, protein MCM10 homolog, MCM10 minichromosome maintenance deficient 1homolog of yeast MCM1hsMCM1minichromosome maintenance complex component 10
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Specificity	Human,Mouse,Rat
Shipping Temperature	Blue Ice
Storage Conditions	Store at -20°C. Avoid freeze / thaw cycles.
Molecular Weight	Observed: 98kDa
Manufacturer - Research Area	Other
Background	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Purification	Affinity purification
Concentration	Batch dependent
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428.1).
Clonality	Polyclonal
NCBI Organism	Homo sapiens

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Menge: 100 uL

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